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Ex (nm)
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-
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Em (nm)
|
-
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分子量
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N/A
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溶劑
|
DMSO
|
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存儲(chǔ)條件
|
在零下15度以下保存, 避免光照
|
|
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產(chǎn)品基本信息
產(chǎn)品名稱：2'，3'-cGAMP琥珀酰亞胺基酯
儲(chǔ)存條件：-15℃避光防潮
保質(zhì)期：12個(gè)月
產(chǎn)品物理化學(xué)光譜特性
分子量：1216.15
外觀：固體
溶劑：DMSO
激發(fā)波長(zhǎng)(nm)：NA
發(fā)射波長(zhǎng)(nm)：NA
2',3'-cGAMP 琥珀酰亞胺酯是一種出色的試劑，可將 2',3'-cGAMP 共價(jià)結(jié)合到生物靶標(biāo)，例如蛋白質(zhì)、肽和核酸。 2',3'-cGAMP 近年來(lái)因其作為癌癥和病毒感染等醫(yī)療靶點(diǎn)的潛力而受到廣泛關(guān)注。它已被證明可以激活免yi系統(tǒng)并增強(qiáng)免yi檢查點(diǎn)抑制劑的功效，這是一種癌癥免yi療法。 2',3'-cGAMP（環(huán)狀 GMP-AMP）是一種環(huán)狀二核苷酸二信使分子，在先天免yi系統(tǒng)中起著至關(guān)重要的作用。它由酶 cGAS（環(huán)狀 GMP-AMP 合酶）合成，以響應(yīng)從受損或感染細(xì)胞中釋放的胞質(zhì) DNA。一旦合成，2',3'-cGAMP 就會(huì)與銜接蛋白 STING（干擾素基因刺激物）結(jié)合并觸發(fā)下游信號(hào)通路，從而產(chǎn)生 I 型干擾素和其他細(xì)胞因子，從而導(dǎo)致針對(duì)入侵病原體的免yi反應(yīng)。
參考文獻(xiàn)
cGAS-STING Pathway as the Target of Immunotherapy for Lung Cancer.
Authors: Dan, Qinfu and Yang, Yang and Ge, Hong
Journal: Current cancer drug targets (2023): 354-362
Spermidine enhances the efficacy of adjuvant in HBV vaccination in mice.
Authors: Ito, Daisuke and Ito, Hiroyasu and Ando, Tatsuya and Sakai, Yasuhiro and Ideta, Takayasu and Ishii, Ken J and Ishikawa, Tetsuya and Shimizu, Masahito
Journal: Hepatology communications (2023)
Discovery of podofilox as a potent cGAMP-STING signaling enhancer with antitumor activity.
Authors: Zhang, Conggang and Han, Jing and Hu, Shuiqing and Hu, Yawei and Xu, Yifang and Hou, Yanfei and Yang, Yinlong and Su, Huili and Zhang, Zhengyin and Liu, Peng and Sun, Xuxu
Journal: Cancer immunology research (2023)
Immunogenicity of small-cell lung cancer associates with STING pathway activation and is enhanced by ATR and TOP1 inhibition.
Authors: Li, Xuetao and Li, Yujun and Zhao, Ziwen and Miao, Nabo and Liu, Guorong and Deng, Liaoyuan and Wei, Shuquan and Hou, Jun
Journal: Cancer medicine (2023): 4864-4881